There are some replies in which prospects ask to remove them from the mailing list, but do not click on the unsubscribe link. Don’t worry though, you can change their status to Unsubscribe in the app. This way you can make sure that you won’t resume a sequence for them, as the system won’t allow you to resume a sequence for a prospect with Unsubscribe status. It’s also impossible to transfer such prospects to another campaign by accident. You can find this option when clicking on Actions -> Unsubscribe:

